Finola Hughes made sporadic appearances as the witches' deceased mother.
James Read played the sisters' perpetually absent father, Victor.
John Cho wooed Holly Marie Combs as a spirit stuck in limbo.
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Misha Collins kicked off his career with "Charmed" before rising to fame on "Supernatural."
Ron Perlman ran his own Underworld academy for an episode.
Julian McMahon played an evil character for a few seasons.
Coolio came back from the dead when he played a Lazarus demon.
Before he was Dwight on "The Office," Rainn Wilson was a demon.
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Amy Adams had a string of bad luck in the early stages of her career as Maggie Murphy.
Zachary Quinto took on a demonic role.
Bruce Campbell went from a horror hero to a supernatural skeptic.
French Stewart played a mischievous genie whose constant tricks caused more harm than good.
Jaime Pressly was a mermaid in season five.
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Before he was McSteamy on "Grey's Anatomy," Eric Dane was on "Charmed."
Norman Reedus went from courting a witch to fighting the living dead.
Melissa George embodied a warrior in season six.
Jenny McCarthy tried to pull off a "Charmed" switch.
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Christina Milian made an appearance in one of her first acting credits.
Rachelle Lefevre started as a ghost before becoming a vampire for "Twilight."
The late James Avery played a compassionate angel double-crossed by Leo.
Balthazar Getty took on a complicated role.
Charisma Carpenter embodied a dangerous demon seeking a new life.
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Kerr Smith played an agent.
Nick Lachey played ghostwriter and columnist Leslie St. Claire.
Billy Zane showed off his charm as ex-demon Drake.
Oded Fehr nearly conquered the Charmed Ones as Zankou.
Janice Dickinson made a surprise appearance at Paige Matthews' funeral.
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Jason Lewis played a dreamy love interest.
Kaley Cuoco betrayed the Charmed Ones as Billie in the final season.
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